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Planta Med 1994; 60(5): 455-459
DOI: 10.1055/s-2006-959531
Paper

© Georg Thieme Verlag Stuttgart · New York

Isolation of Bis-Indole Alkaloids with Antileishmanial and Antibacterial Activities from Perschiera van heurkii (Syn. Tabernaemontana van heurkii)

V. Muñoz1 , C. Moretti1 , 2 , 3 , M. Sauvain1 , 2 , C. Caron3 , A. Porzel3 , G. Massiot3 , B. Richard3 , L. Le Men-Olivier3
  • 1Insituto Boliviano de Biologia de Altura (IBBA), CP 717, La Paz, Bolivia
  • 2Institut Français de Recherche Scientifique pour le Développement en Coopération (ORSTOM), Département Santé, 213 rue La Fayette, F-75480 Paris Cedex 10, France
  • 3Laboratoire de Pharmacognosie, associé au CNRS - URA 492, Faculté de Pharmacie, 51 rue Cognacq Jay, F-51096 - Reims Cedex, France
Further Information

Publication History

1993

1994

Publication Date:
04 January 2007 (online)

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Abstract

Extracts from leaves and stem bark of Peschiera van heurkii (Muell. Arg.) L. Allorge (syn. Tabernaemontana van heurkii Muell. Arg., Apocynaceae) have been assayed for antileishmanial and antibacterial activities. The activities were concentrated in the alkaloid fractions which yielded 20 indole and bis-indole alkaloids. The strongest leishmanicidal and antibacterial activities were observed with the dimeric alkaloids conodurine (1), N-demethylconodurine (= gabunine) (2), and conoduramine (3). Weak toxicity towards macrophage host cells and strong activity against the intracellular amastigote form of Leishmania were observed for compounds 1 and 2. In vivo, 1 was less active than glucantime (= N-methylglucamine antimonate), the drug of reference, while 2 was devoid of activity at l00 mg/kg.

Key words

Peschiera van heurkii - Tabernaemontana - Apocynaceae - bis-indole alkaloids - conodurine - gabunine - conoduramine - leishmanicidal - antibacterial activities - Leishmania amazonensis - Leishmania braziliensis