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Planta Med 1994; 60(6): 561-565
DOI: 10.1055/s-2006-959572
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© Georg Thieme Verlag Stuttgart · New York

Pharmacological and Phytochemical Studies of Cephäelis axillaris

M. Luisa Martín1 , Mahabir P. Gupta2 , Ana V. Ortiz de Urbina1 , George A. Karikas2 , Marina Gordaliza3 , José M. Miguel del Corral3 , Luis San Román1 , Ceferino Sánchez2 , Arturo San Feliciano3
  • 1Laboratorio de Fermacognosia y Farmacodinamia, Facultad de Farmacia, Universidad de Salamanca, E-37007 Salamanca, Spain
  • 2CIFLORPAN, Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Panamá
  • 3Laboratorio de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, E-37007 Salamanca, Spain
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Publication History

1993

1994

Publication Date:
05 January 2007 (online)

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Abstract

The most significant effect, observed in the preliminary pharmacological evaluation of the whole ethanol extract and the alkaloidal fraction of Cephäelis axillaris, was the hyperemia of ears and external mucosas which was most probably due to an α-adrenergic blocking activity. In addition, both samples also induced a marked hypotension in normotensive as well as hypertensive (SHR) rats and inhibited the increases of blood pressure induced by i. v.. administration of noradrenaline in pithed rats.

The structures of the major alkaloidal components of the extract were elucidated on the basis of chemical characterization assays and IR, UV, 1H and 13C one and two-dimensional NMR analyses.

Key words

Cephäelis axillaris - Rubiaceae - hyperemia - antihypertensive - indole alkaloids