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Planta Med 1993; 59(1): 37-41
DOI: 10.1055/s-2006-959600
Paper

© Georg Thieme Verlag Stuttgart · New York

Prevention of Galactosamine-Induced Hepatic Damage by Picroliv: Study on Bile Flow and Isolated Hepatocytes (ex vivo)1

P. K. S. Visen, Binduja Shukla, G. K. Patnaik, B. N. Dhawan
  • ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Post Box No 173, Lucknow-226001, India
1 CDRI Communication No. 4855
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Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

Picroliv, a standardized extract from the plant Picrorhiza kurrooa containing active constituents, showed a significant dose dependent (3- 12 mg/kg p.o. × 7) protective activity against galactosamine-induced hepatic damage in rat as evaluated on the isolated hepatocytes (ex vivo) preparation. It markedly increased the percentage of viability of hepatocytes. It also restored the galactosamine-induced changes in the levels of enzymes (GOT, GPT and alkaline phosphatase) both in isolated hepatic cells as well as in serum. In addition, picroliv possessed a marked anticholestatic effect. Picroliv was found to be more potent than silymarin, a standard hepatoprotective agent.

Key words

Picrorhiza kurrooa - picroliv - hepatoprotective activity - anticholestatic activity - galactosamine-induced liver damage - iridoid glycosides - picroside I - kutkoside