Planta Medica, Inhaltsverzeichnis Planta Med 1993; 59(1): 37-41DOI: 10.1055/s-2006-959600 Paper © Georg Thieme Verlag Stuttgart · New York Prevention of Galactosamine-Induced Hepatic Damage by Picroliv: Study on Bile Flow and Isolated Hepatocytes (ex vivo)1 P. K. S. Visen, Binduja Shukla, G. K. Patnaik, B. N. Dhawan ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Post Box No 173, Lucknow-226001, India 1 CDRI Communication No. 4855 Artikel empfehlen Abstract als PDF herunterladen Artikel einzeln kaufen Abstract Picroliv, a standardized extract from the plant Picrorhiza kurrooa containing active constituents, showed a significant dose dependent (3- 12 mg/kg p.o. × 7) protective activity against galactosamine-induced hepatic damage in rat as evaluated on the isolated hepatocytes (ex vivo) preparation. It markedly increased the percentage of viability of hepatocytes. It also restored the galactosamine-induced changes in the levels of enzymes (GOT, GPT and alkaline phosphatase) both in isolated hepatic cells as well as in serum. In addition, picroliv possessed a marked anticholestatic effect. Picroliv was found to be more potent than silymarin, a standard hepatoprotective agent. Key words Picrorhiza kurrooa - picroliv - hepatoprotective activity - anticholestatic activity - galactosamine-induced liver damage - iridoid glycosides - picroside I - kutkoside PDF (381 kb)
