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Planta Med 1993; 59(1): 42-45
DOI: 10.1055/s-2006-959601
Paper

© Georg Thieme Verlag Stuttgart · New York

Isolation and Biological Effects of 7-O-Methyleriodictyol, a Flavanone Isolated from Artemisia monosperma, on Rat Isolated Smooth Muscles

L. Abu-Niaaj1 , M. Abu-Zarga2 , S. Sabri2 , S. Abdalla1
  • 1Department of Biological Sciences, University of Jordan, Amman, Jordan
  • 2Department of Chemistry, University of Jordan, Amman, Jordan
Further Information

Publication History

1991

1992

Publication Date:
04 January 2007 (online)

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Abstract

The isolation for the first time from the genus Artemisia (Compositae) of the known flavanone, 7-O-methyleriodictyol (7-methoxy-5,3′,4′-trihydroxy-flavanone), its identification, and its biological effects on rat isolated smooth muscles are described. 7-O-Methyleriodictyol (10-7 M to 3 × 10-4 M) caused concentration-dependent inhibition of the amplitude of the phasic contractions and reduced the tone of the ileum, the uterus, and the urinary bladder. It also caused relaxation of the phenylephrine-precontracted pulmonary artery and the acetylcholine-precontracted trachea. The flavanone also shifted to the right the acetylcholine concentration-effect curve on the ileum and the oxytocin concentration-effect curve on the uterus. The maximum contractions induced by acetylcholine or oxytocin were also inhibited by 7-O-methyleriodictyol. These antispasmodic effects are partly consistent with the use of A. monosperma in folk medicine for certain gastrointestinal disorders.

Key words

Artemisia monosperma - flavanone - 7-O-methyleriodictyol - antispasmodic activity - isolated smooth muscle