Strychnopentamine, a Potential Anticancer Agent

J. Quetin-Leclercq; B. Bouzahzah; A. Pons; R. Greimers; L. Angenot; R. Bassleer; H. Barbason

doi:10.1055/s-2006-959605

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Planta Med 1993; 59(1): 59-62
DOI: 10.1055/s-2006-959605

Paper

Strychnopentamine, a Potential Anticancer Agent

J. Quetin-Leclercq¹ , B. Bouzahzah² , A. Pons² , R. Greimers² , L. Angenot¹ , R. Bassleer³ , H. Barbason²

¹Laboratoire de Pharmacognosie, Institut de Pharmacie, Université de Liège, rue Fusch, 5, B-4000 Liège, Belgium
²Département d'Anatomie Pathologique, Université de Liège, Tour de Pathologic B23, B-4000 Liège, Belgium
³Laboratoire d'Histologie et de Cytologie, Faculté de Médecine, Université de Liège, rue de Pitteurs, 20, B-4020 Liège, Belgium

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Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

We analysed the effects of Strychnopentamine, an alkaloid isolated from Strychnos usambarensis, on an Ehrlich ascites tumor growing in the mouse after inoculation. Four subcutaneous injections of 1.5 mg Strychnopentamine (1 per day) induce a significant decrease of the number of tumor cells and a significant increase of the survival of the treated mice. Observed side effects are partial haemolysis and some liver damage.

Key words

Strychnopentamine - indole alkaloid Strychnos usambarensis - anticancer activity - Ehrlich ascites tumor