Planta Med 1993; 59(2): 152-154
DOI: 10.1055/s-2006-959632
Papers

© Georg Thieme Verlag Stuttgart · New York

Effects of Kampo (Japanese Herbal) Medicine “Sho-Saiko-To” on DNA-Synthesizing Enzyme Activity in 1,2-Dimethylhydrazine-Induced Colonic Carcinomas in Rats

Shinobu Sakamoto1 , Takao Mori2 , Keiko Sawaki3 , Yasuyuki Kawachi1 , Katsuhiko Kuwa1 , Hideki Kudo1 , Satoe Suzuki1 , Yoshie Sugiura1 , Noriyuki Kasahara1 , Hiroshi Nagasawa3
  • 1Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113, Japan
  • 2Zoological Institute, Faculty of Science, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan
  • 3Experimental Animal Research Laboratory, Meiji University, Tama-ku, Kawasaki, Kanagawa 214, Japan
Further Information

Publication History

1992

1992

Publication Date:
04 January 2007 (online)

Abstract

Sho-Saiko-To (SST) is a modified Japanese traditional Chinese herbal medicine containing seven medical plants: Bupleuri radix, Pinelliae tuber, Suxtallariae radix, Zizyphi fructus, Ginseng radix, Glycyrrhizae radix, and Zingiberis recens rhizoma. This preparation has been used in the treatment of some inflammatory diseases of the respiratory system and chronic hepatitis. In the present study, the effects of SST were investigated on the activities of DNA-synthesizing enzymes in 1,2-dimethylhydrazine (DMH)-induced colonic carcinomas in rats. Six-week administration of SST prevented nearly 100% of the body weight loss and the final number of the colonic carcinomas compared to those in the rats treated with DMH alone, and suppressed the enhanced activities of thymidylate synthetase (TS) and thymidine kinase (TK) which were involved in the de novo and salvage pathways of pyrimidine synthesis, respectively, in DMH-induced colonic carcinomas. These results indicate that SST may show directly and/or indirectly inhibitory effects on the development of colonic carcinomas.