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Planta Med 1993; 59(3): 256-258
DOI: 10.1055/s-2006-959663
Paper

© Georg Thieme Verlag Stuttgart · New York

Bioactive Diterpenoids Isolated from Dilophus ligulatus

Noureddine Bouaïcha1 , 4 , Corrado Tringali2 , Danielle Pesando1 , Monique Malléa1 , Christos Roussakis3 , Jean François Verbist3
  • 1INSERM U303 “Mer et Santé” B.P. 3, F-06230 Villefranche-sur-mer, France
  • 2Dipartimonto di Scienze Chimiche, Università di Catania, viale A. Doria 8, I-95125 Catania, Italy
  • 3S.M.A.B. Groupe de Recherche sur les Substances Marines à Activité Biologique, Université de Nantes-Faculté de Pharmacie, B.P. 1024, 1 rue G. Veil, F-44035 Nantes, France
  • 4Address for correspondence
Further Information

Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

Nine diterpenoids, acetyldictyolal (1), epoxyoxodolabelladiene (2), dictyotalide B (3), neodictyolactono (4), pachylactone (5), the acetals 6a and 6b, isoacetoxycrenulatin (7), and dictyolactone (8) were isolated from the brown alga Dilophus ligulatus (Kütz.) Feldm. Their structures have been elucidated by comparison of mass, IR, 1H- and 13C-NMR spectra with reported literature data. Compounds 1, 2, 4, 7, and 8 exhibited antifungal activity. Cytotoxic activity against several types of mammalian cells (KB, P-388, P-388/DOX, and NSCLCN6-L16) in culture was examined for the 8 diterpenoids. Some of them showed stronger cyto-toxicity than mercaptopurine which was used as a positive control in this study.

Key words

Dilophus ligulatus - diterpenoids - anti-fungal activity - cytotoxic activity - brown algae.