Structure-Related Inhibiting Activity of Some Tobacco Cembranoids on the Prostaglandin Synthesis in vitro

Elisabeth Olsson; Anne Holth; Eva Kumlin; Lars Bohlin; Inger Wahlberg

doi:10.1055/s-2006-959684

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Planta Med 1993; 59(4): 293-295
DOI: 10.1055/s-2006-959684

Papers

Structure-Related Inhibiting Activity of Some Tobacco Cembranoids on the Prostaglandin Synthesis in vitro

Elisabeth Olsson¹ , Anne Holth² , Eva Kumlin² , Lars Bohlin² , Inger Wahlberg¹

¹Reserca AB, S-118 84 Stockholm, Sweden
²Department of Pharmacognosy, Biomedical Center, Uppsala University, Box 579, S-751 23 Uppsala, Sweden

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Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

Structure-related inhibitory effects on the prostaglandin synthesis in vitro have been detected among eight diterpenoids of the cembrane class (1-8). The 4,6-diols 1 and 2 are the most active of the cembranoids studied with IC₅₀ values of 0.36 and 0.39mM, respectively, as compared with an IC₅₀ value of 1.4 for acetylsalicylic acid. Lower activities are found for cem-branoids having undergone oxidation of/at the 11,12 double bond (5-8), while the 4-hydroxy-6-oxocem-branoids 3 and 4 exhibit effects lower than those of 1 and 2 but higher than those of 5-8.

Key words

Nicotiana tabacum - cembranoids - prostaglandin synthesis inhibition