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Planta Med 1993; 59(4): 312-314
DOI: 10.1055/s-2006-959688
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© Georg Thieme Verlag Stuttgart · New York

Free Radical Scavenger and Antihepatotoxic Activity of Rosmarinus tomentosus

M. Concepción Navarro, M. Pilar Montilla, Antonina Martín, José Jiménez, M. Pilar Utrilla
  • Departamento de Farmacología, Facultad de Farmacia, Universidad de Granada, Campus de Cartuja, E-18071 Granada, Spain
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Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

The free radical scavenger and anti-hepatotoxic activity from Rosmarinus tomentosus ethanolic extract and its fractions were studied, and also its membrane stabilizing activity in rat erythrocytes. Pre-trcatment with an ethanolic extract of R. tomentosus caused an important decrease in the CCl4-induced toxicity in rats liver, made evident by its effect on the levels of GPT and bilirubin in the serum and the malondialdehyde (MDA) concentration in the liver. These effects are similar to those produced by silymarin. The chloroformic fraction showed the greatest anti-hepatotoxic activity and the ethyl acetate fraction the greatest free radical scavenger activity.

Key words

Rosmarinus tomentosus - free radical scavengers - antihepatotoxic activity - membrane stabilizing activity