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Planta Med 1993; 59(4): 315-317
DOI: 10.1055/s-2006-959689
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© Georg Thieme Verlag Stuttgart · New York

Protection of Phenylpropanoid Glycosides from Pedicularis Against Oxidative Hemolysis in Vitro

Li Ji1 , Wang Pan-fen1 , Zheng Rong-liang1 , Liu Zi-min2 , Jia Zhong-jian2
  • 1Department of Biology, Lanzhou University, Lanzhou 730000, People's Republic of China
  • 2Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China
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Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

Five phenylpropanoid glycosides from Pedicularis, isoacteoside (1), acteoside (2), echinacoside (3), pedicularioside A (4), cistanoside D (5), and a chemically synthesised compound, permethylacteoside (6), as phenolic compounds can protect against oxidative hemolysis. The inhibitory activity is related to the number of phenolic hydroxy groups. Compounds 1,2,3, and 4, possessing four phenolic hydroxy groups, have stronger inhibitory activities than 5 possessing only two phenolic hydroxy groups, and compound 6 with no phenolic hydroxy group inhibited oxidative hemolysis weakly.

Key words

Phenylpropanoid glycosides - Pedicularis - oxidative hemolysis - free radicals - 2,2′-azo-bis(2-ami-dinopropane) dihydrochloride (AAPH)