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Planta Med 1993; 59(4): 326-329
DOI: 10.1055/s-2006-959692
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© Georg Thieme Verlag Stuttgart · New York

Evaluation of the Central Properties of Artemisia verlotorum 1

Thereza C. M. de Lima, Gina S. Morato, Reinaldo N. Takahashi
  • Department of Pharmacology, University of Santa Catarina, R. Ferreira Lima, 82, Centro, Florianópolis, SC, 88015-420, Brazil
1 Part of this work was presented at the Xth Simpãsio Brasileiro de Plantas Medicinais, São Paulo, SP, Brazil, 1988
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Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

The anticonvulsive activity of the crude hydroalcoholic extract (HE) of Artemisia verlotorum (Compositae) was analysed as a part of a psychophar-macological screening of this plant. High doses of HE (2 g/kg) prevented the onset of electroshock (75 mA, 60 Hz) and pentylenetretazole-induced (75 mg/kg i.p.) convulsions and also increased the latencies to convulsions induced by 3-mercaptopropionic acid (30 mg/ kg i.p.) and pilocarpine (400 mg/kg i.p.) in mice. In addition, HE caused marked hypothermic and analgesic effects in these animals. Thus, the HE of A. verlotorum showed a protective effect against experimental convulsions elicited by various agents, as well as analgesic and hypothermic actions. These findings partially support the popular use of Artemisia verlotorum as an anti-convulsant and analgesic.

Key words

Artemisia verlotorum - hydroalcoholic extract - convulsions - pain threshold - core temperature - rat - mouse