Metabolism of Strychnine N-Oxide and Brucine N-Oxide by Human Intestinal Bacteria

Sahar El-Mekkawy; M. R. Meselhy; Yukio Kawata; Shigetoshi Kadota; Masao Hattori; Tsuneo Namba

doi:10.1055/s-2006-959698

Planta Medica, Inhaltsverzeichnis

Planta Med 1993; 59(4): 347-350
DOI: 10.1055/s-2006-959698

Papers

Metabolism of Strychnine N-Oxide and Brucine N-Oxide by Human Intestinal Bacteria

Sahar El-Mekkawy, M. R. Meselhy, Yukio Kawata, Shigetoshi Kadota, Masao Hattori, Tsuneo Namba

Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-01, Japan

Abstract

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Abstract

Anaerobic incubation of strychnine N-oxide with human intestinal bacteria resulted in its transformation to strychnine and 16-hydroxystrychnine. Similarly, brucine N-oxide was transformed to brucine and 16-hydroxybrucine.

Key words

Strychnine N-oxide - brucine N-oxide - metabolism - Lactobacillus acidophilus - strychnine - 16-hydroxystrychnine - brucine - 16-hydroxybrucine - Strych-nos nux-vomica - Loganiaceae

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