Planta Medica, Inhaltsverzeichnis Planta Med 1993; 59(5): 421-424DOI: 10.1055/s-2006-959723 Paper © Georg Thieme Verlag Stuttgart · New York Protective Effect of Dunaliella bardawil on Water-Immersion-Induced Stress in Rats Hiroyuki Takenaka1 , Hidehiro Takahashi1 , Katsuhiko Hayashi1 , Ami Ben-Amotz2 1Department of Research and Development, Nikken Sohonsha Corp., 1-32 Asahira, Fukuju, Hashima, Gifu, Japan 2National Institute of Oceanography, Israel Oceanographic & Limnological Research, Tel-Shikmona, P.O.B. 8030, Haifa 31080, Israel Artikel empfehlen Abstract als PDF herunterladen Artikel einzeln kaufen Abstract The functional activity of a natural isomer mixture as compared with synthetic all-trans β-carotene in rats was investigated in a rat model produced by water-immersion restraint stress. Five-week-old male rats were fed diets supplemented with synthetic all-trans β-carotene, dry Dunaliella bardawil, and purified natural β-carotene from D. bardawil at equivalent levels of β-carotene. After the rats were fed diets containing up to 0.1% β-carotene for 2 weeks, they were restrained in a wire cage and immersed in a 23°C water bath for 20 h. Liver analyses indicated that rats showed higher accumulations of the algal β-carotene isomer mixture than of the synthetic all-trans β-carotene. Dunaliella bardawil and purified natural β-carotene significantly decreased the gastric mucosal lesions. Synthetic β-carotene did not decrease the lesions. These results suggest that the gastric cytoprotective effect of β-carotene depends on the amount of β-carotene accumulated in the body. Key words Dunaliella bardawil - natural β-carotene - gastric cytoprotective effect - liver storage - 9-cis-β-carotene PDF (75 kb)
