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Planta Med 1993; 59(5): 425-427
DOI: 10.1055/s-2006-959724
Paper

© Georg Thieme Verlag Stuttgart · New York

Suppression by Kampo Medicines in Preneoplastic Mammary Hyperplastic Alveolar Nodules of SHN Virgin Mice

Shinobu Sakamoto1 , Naoka Muroi2 , Manabu Matsuda3 , Masaru Tajima2 , Hideki Kudo1 , Noriyuki Kasahara1 , Satoe Suzuki1 , Yoshie Sugiura1 , Katsuhiko Kuwa1 , Hideo Namiki4 , Takao Mori3 , Seiichiro Kawashima3 , Hiroshi Nagasawa2
  • 1Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113, Japan
  • 2Experimental Animal Research Laboratory, Meiji University, Tamaku, Kawasaki, Kanagawa 214, Japan
  • 3Zoological Institute, Faculty of Science, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan
  • 4Department of Biology, School of Education, Waseda University, 1-6-1, Nishiwaseda, Shinjuku-ku, Tokyo 160, Japan
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Publikationsverlauf

1992

1993

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

Sho-saiko-to (SST), Keishi-bukuryo-gan (KBG), and Shakuyaku-kanzo-to (SKT) are Japanese modified traditional Chinese herbal medicines (Kampo medicines) consisting of 7, 5, and 2 medical plants, respectively. It is known that the hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in the mammary glands of mice. We examined the effects of SST, KBG, and SKT on the formation and growth of HAN in a high-mammary-tumor strain of SHN virgin mice. Oral administration of SST for 60 days beginning at 90 days of age reduced the number and area of HAN and mammary thymidylate synthetase activity with a reduction of serum prolactin level. There was little difference between the other experimental groups and the control in the formation and growth of HAN and the enzyme activities. These results indicate that SST may have a preventive effect on malignant mammary transformations.

Key words

Kampo medicine - Sho-saiko-to - hyperplastic alveolar nodule (HAN) - thymidylate synthetase - mice