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Planta Med 1993; 59(5): 447-450
DOI: 10.1055/s-2006-959729
Paper

© Georg Thieme Verlag Stuttgart · New York

Biological Activities of Terthiophenes and Polyynes from the Asteraceae

J. B. Hudson1 , E. A. Graham1 , R. Rossi2 , A. Carpita2 , D. Neri2 , G. H. N. Towers3
  • 1Division of Medical Microbiology, University of British Columbia, 2733 Heather Street, Vancouver, B. C. Canada V5Z 1M9
  • 2Dipartimento di Chimica e Chimica Industriale, University of Pisa, Pisa, Italy
  • 3Department of Botany, University of British Columbia, Vancouver, B.C. Canada V6T 1W5
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Publication History

1992

1993

Publication Date:
04 January 2007 (online)

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Abstract

We evaluated a number of terthiophenes and polyynes, from the Asteraceae, for biological activities against microorganisms, viruses, and tumor cells, with and without the aid of UVA (long wavelength ultraviolet) radiation. The terthiophenes, which represented the basic α-terthienyl nucleus with simple side chains, showed impressive UVA-dependent activities, some of which were superior to α-terthienyl itself. In contrast, the polyynes had no significant biological activity, with or without UVA. We believe that these terthiophenes would be worthwhile evaluating in animal models of infectious diseases.

Key words

Asteraceae - polyynes - terthiophenes - biological activities - UVA light