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Planta Med 1991; 57(1): 56-58
DOI: 10.1055/s-2006-960018
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© Georg Thieme Verlag Stuttgart · New York

Platelet Aggregation Inhibitors from the Seeds of Swietenia mahagoni: Inhibition of in vitro and in vivo Platelet-Activating Factor-Induced Effects of Tetranortriterpenoids Related to Swietenine and Swietenolide

Hisao Ekimoto1 , Yukio Irie1 , Yumiko Araki1 , Gui-Qiu Han2 , Shigetoshi Kadota3 , Tohru Kikuchi3
  • 1Research Laboratories, Nippon Kayaku Co., Ltd., Shimo 3-31-12, Kita-ku, Tokyo 115, Japan
  • 2Department of Pharmaceutical Sciences, Beijing Medical College, Beijing, People's Republic of China
  • 3Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan
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Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

The ether extract from the seeds of Swietenia mahagoni Jacq. (Meliaceae) was found to inhibit platelet-activating factor (PAF)-induced platelet aggregation. Systematic separation of the extract afforded twenty eight tetranortriterpenoids related to swietenine and swietenolide. Among them, several new compounds, named swietemahonin A, D, E, and G and 3-O-acetylswietenolide and 6-O-acetylswietenolide, showed a strong inhibition against PAF-induced aggregation in vitro and in vivo assays.

Key words

Swietenia mahagoni - platelet-activating factor - platelet aggregation - tetranortriterpenoids - swietemahonin A, D, E, G, 3-O- and 6-O-acetyl-swietenolides