Improvement of Hyperglycemia and Hyperlipemia in Streptozotocin-Diabetic Rats by a Methanolic Extract of Prunus davidiana Stems and Its Main Component, Prunin

Jae Sue Choi; Takako Yokozawa; Hikokichi Oura

doi:10.1055/s-2006-960075

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Planta Med 1991; 57(3): 208-211
DOI: 10.1055/s-2006-960075

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Improvement of Hyperglycemia and Hyperlipemia in Streptozotocin-Diabetic Rats by a Methanolic Extract of Prunus davidiana Stems and Its Main Component, Prunin

Jae Sue Choi¹ , Takako Yokozawa³ , Hikokichi Oura³

¹Department of Nutrition and Food Sciences, National Fisheries University of Pusan, Pusan 608-023, Korea
³Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01, Japan

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Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

Blood glucose and total lipid levels in rats with streptozotocin-induced diabetes were determined after intraperitoneal administration of a methanolic extract of Prunus davidiana Fr. stems and its main component, prunin (= naringenin 7-O-β-D-glucoside). From the data obtained it was concluded that intraperitoneal administration of the methanolic extract and prunin produced a significant hypoglycemic effect. Total blood lipids were also decreased by these substances. Thus, it is suggested that this methanolic extract contains one or more hypoglycemic principles including the main flavanone glycoside, prunin, which can significantly reduce the levels of blood glucose and total lipids in streptozotocin-diabetic rats.

Key words

Prunus davidiana - Rosaceae - hypoglycemic effect - hypolipemic effect - prunin - streptozotocin-induced diabetic rats