Inhibitory Effects of Licochalcone A Isolated from Glycyrrhiza inflata Root on Inflammatory Ear Edema and Tumour Promotion in Mice

Shoji Shibata; Hideo Inoue; Susumu Iwata; Rundi Ma; Lijian Yu; Hisao Ueyama; Junko Takayasu; Teiko Hasegawa; Harakuni Tokuda; Atsuko Nishino; Hoyoku Nishino; Akio Iwashima

doi:10.1055/s-2006-960078

Planta Med 1991; 57(3): 221-224
DOI: 10.1055/s-2006-960078

Papers

Inhibitory Effects of Licochalcone A Isolated from Glycyrrhiza inflata Root on Inflammatory Ear Edema and Tumour Promotion in Mice

Shoji Shibata¹ , Hideo Inoue² , Susumu Iwata² , Rundi Ma³ ^, ⁴ , Lijian Yu³ ^, ⁴ , Hisao Ueyama⁵ , Junko Takayasu³ , Teiko Hasegawa³ , Harakuni Tokuda³ , Atsuko Nishino³ , Hoyoku Nishino³ , Akio Iwashima³

¹Shibata Laboratory of Natural Medicinal Materials, c/o Minophagen Pharmaceutical Co., No. 3 Tomizawa Bldg. 4th Fl., Yotsuya 4-2-7, Shinjuku-ku, Tokyo 160, Japan
²Research Laboratory of Minophagen Pharmaceutical Co., Komatsubara, Zama-shi, Kanagawa 228, Japan
³Department of Biochemistry, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602, Japan
⁴Department of Biochemistry, Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology, Xian, People's Republic of China
⁵Department of Biochemistry, Shiga University of Medicine, Seta, Ohtsu, Shiga 520-21, Japan

Abstract

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Abstract

Licochalcone A, 3-α,α-dimethylallyl-4,4′-dihydroxy-6-methoxychalcone, from the root of Glycyrrhiza inflata Beta (Leguminosae) (Xin-jiang liquorice) showed anti-inflammatory action towards mouse ear edema induced by arachidonic acid (AA) and 12-O-tetradecanoylphorbol 13-acetate (TPA) by topical application. Anti-tumour promoting action of licochalcone A was also observed in vivo for mouse skin papilloma initiated by dimethylbenz[a]anthracene (DMBA) and promoted by TPA. It inhibited in vitro ³²P_i-incorporation to phospholipids in HeLa cells promoted by TPA. A competitive interaction of licochalcone A with the TPA-receptors in the cell membrane has been suggested.

Key words

Glycyrrhiza inflata - licochalcone A - anti-inflammatory action - anti-tumour promoting action

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