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Planta Med 1991; 57(3): 221-224
DOI: 10.1055/s-2006-960078
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© Georg Thieme Verlag Stuttgart · New York

Inhibitory Effects of Licochalcone A Isolated from Glycyrrhiza inflata Root on Inflammatory Ear Edema and Tumour Promotion in Mice

Shoji Shibata1 , Hideo Inoue2 , Susumu Iwata2 , Rundi Ma3 , 4 , Lijian Yu3 , 4 , Hisao Ueyama5 , Junko Takayasu3 , Teiko Hasegawa3 , Harakuni Tokuda3 , Atsuko Nishino3 , Hoyoku Nishino3 , Akio Iwashima3
  • 1Shibata Laboratory of Natural Medicinal Materials, c/o Minophagen Pharmaceutical Co., No. 3 Tomizawa Bldg. 4th Fl., Yotsuya 4-2-7, Shinjuku-ku, Tokyo 160, Japan
  • 2Research Laboratory of Minophagen Pharmaceutical Co., Komatsubara, Zama-shi, Kanagawa 228, Japan
  • 3Department of Biochemistry, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602, Japan
  • 4Department of Biochemistry, Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology, Xian, People's Republic of China
  • 5Department of Biochemistry, Shiga University of Medicine, Seta, Ohtsu, Shiga 520-21, Japan
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Publikationsverlauf

1990

Publikationsdatum:
05. Januar 2007 (online)

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Abstract

Licochalcone A, 3-α,α-dimethylallyl-4,4′-dihydroxy-6-methoxychalcone, from the root of Glycyrrhiza inflata Beta (Leguminosae) (Xin-jiang liquorice) showed anti-inflammatory action towards mouse ear edema induced by arachidonic acid (AA) and 12-O-tetradecanoylphorbol 13-acetate (TPA) by topical application. Anti-tumour promoting action of licochalcone A was also observed in vivo for mouse skin papilloma initiated by dimethylbenz[a]anthracene (DMBA) and promoted by TPA. It inhibited in vitro 32Pi-incorporation to phospholipids in HeLa cells promoted by TPA. A competitive interaction of licochalcone A with the TPA-receptors in the cell membrane has been suggested.

Key words

Glycyrrhiza inflata - licochalcone A - anti-inflammatory action - anti-tumour promoting action