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Planta Med 1991; 57(3): 247-249
DOI: 10.1055/s-2006-960083
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© Georg Thieme Verlag Stuttgart · New York

6-Pentadecylsalicylic Acid; An Antithrombin Component Isolated from the Stem of Rhus semialata varroxburghii

Sheng-Chu Kuo1 , 5 , Che-Ming Teng2 , 5 , Lih-Gen Lee2 , Tai-Hui Chiu1 , Tian-Shung Wu3 , Shung-Chueh Huang1 , Jin-Bin Wu1 , Tiaur-Yarng Shieh1 , Ruey-Ju Chang1 , Teh-Chang Chou4
  • 1Graduate Institute of Pharmaceutical Chemistry, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, Republic of China
  • 2Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
  • 3Department of Chemistry, National Cheng-Kung University, Tainan, Taiwan, Republic of China
  • 4Department of Chemistry, Tunghai University, Taichung, Taiwan, Republic of China
  • 5National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China
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1990

Publikationsdatum:
05. Januar 2007 (online)

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Abstract

Bioassay-directed fractionation of the n-hexane extract of the stem of Rhus semialata Murr. var. roxburghii DC (Anacardiaceae) has led to the isolation of 6-pentadecylsalicylic acid. It showed antithrombin activity at 50 µg/ml in the amidolytic method. It also prolonged the clotting time in a dose-dependent manner in the clotting assay of thrombin-fibrinogen interaction.

Key words

6-Pentadecylsalicylic acid - antithrombin - amidolytic method - clotting time - lanatebulic acid - Rhus semialata