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Planta Med 1991; 57(4): 305-308
DOI: 10.1055/s-2006-960103
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© Georg Thieme Verlag Stuttgart · New York

Inhibition of Gastric H+,K+-ATPase and Acid Secretion by Ellagic Acid

Shigeru Murakami, Yoshihiko Isobe, Haruko Kijima, Hanahumi Nagai, Makoto Muramatu, Susumu Otomo
  • Research Center, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Ohmiya, Saitama 330, Japan
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Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

The effects of ellagic acid on gastric H+,K+-ATPase, acid secretion, and the occurrence of gastric ulcers were studied. Ellagic acid inhibited hog gastric H+,K+-ATPase activity with a 50% inhibition at 2.1 × 10-6M; kinetic studies showed that the inhibition of H+,K+-ATPase by ellagic acid is competiive with respect to ATP and is noncompetitive with respect to K+. The effect on gastric ulcers was investigated by using a stress ulcer model. Intraperitoneal administration of ellagic acid at above 5 mg/kg markedly reduced the occurrence of gastric lesion. Ellagic acid significantly reduced acid secretion at the same doses. These results suggest that ellagic acid has a marked inhibitory effect on acid secretion and the occurrence of stress-induced gastric lesions, and these effects may be attributed to the inhibition of H+,K+-ATPase activity.

Key words

Ellagic acid - H+ - K+-ATPase - antiulcer activity - antisecretory activity