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Planta Med 1991; 57(4): 315-316
DOI: 10.1055/s-2006-960105
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© Georg Thieme Verlag Stuttgart · New York

An Experimental Evaluation of Possible Teratogenic Potential in Boerhaavia diffusa in Albino Rats

Anubha Singh1 , R. G. Singh1 , R. H. Singh1 , N. Mishra2 , N. Singh2
  • 1Department of Nephrology and Kayachikitsa, Institute of Medical Sciences, Banaras University, Varanasi, India
  • 2Department of Pharmacology and Therapeutics, King George's Medical College, Lucknow 226003, India
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Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

The present study was undertaken to evaluate any possibility of teratogenic effects in Boerhaavia diffusa (Punarnava), a widely used herbal medicine for renal and urinary tract diseases by Ayurvedic physicians in India. The ethanolic extract of Boerhaavia diffusa (BDE) was administered daily in a dose of 250 mg/kg, body weight p. o., to pregnant albino female rats during the entire period of gestation. BDE was found to be devoid of any teratogenic effect as litter size and survival rate of foetuses were the same as for the normal control group and no foetal anomaly could be detected.

Key words

Boerhaavia diffusa. albino rats - teratogenicity