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Planta Med 1991; 57(4): 335-336
DOI: 10.1055/s-2006-960111
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© Georg Thieme Verlag Stuttgart · New York

Immunomodulatory Activity of Polysaccharide from Acanthopanax obovatus Roots

J. Z. Wang1 , X. J. Mao2 , H. Ito1 , K. Shimura3
  • 1Department of Pharmacology, Mie University School of Medicine, Tsu, Mie 514, Japan
  • 2Department of Microbiology, Lanzhou Medical College, Lanzhou, People's Republic of China
  • 3Institute of Laboratory Animals, Mie University School of Medicine, Tsu, Mie 514, Japan
Further Information

Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

The effects of the Acanthopanax obovatus polysaccharide (AOPS) as well as its combination with cyclophosphamide (CY) or prednisolone on immune responses were investigated in mice. AOPS (250 mg/kg i.p. × 5) increased the spleen weight and the number of spleen cells, and augmented the phagocytosis of peritoneal macrophages both in normal mice and in immunosuppressed mice. In a haemagglutinin assay AOPS increased the production of specific antibodies and antagonized the suppressive effect of CY. AOPS not only enhanced the degree of in vitro spleen cell-mediated red blood cells (SRBC) hemolysis (quantitative hemolysis of SRBC) but also restored the suppressive effect of CY completely. From these results, AOPS was shown to have an enhancing and a modulating activity on immune responses.

Key words

Acanthopanax obovatus - immunomodulatory activity - phagocytosis - haemagglutinin titer