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Planta Med 1991; 57(5): 406-408
DOI: 10.1055/s-2006-960135
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© Georg Thieme Verlag Stuttgart · New York

Bioactive Principles from the Roots of Lindera megaphylla

C. C. Chen1 , Y. L. Huang1 , J. C. Ou1 , M. J. Su2 , S. M. Yu2 , C. M. Teng2
  • 1National Research Institute of Chinese Medicine, 2 Lane 391, Pei-I Rd. Sec. 2, Hsintein, Taipei Hsien, Taiwan 23177, Republic of China
  • 2Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
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Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

d-Dicentrine was isolated from the root of Lindera megaphylla. It inhibited the aggregation of washed rabbit platelets induced by ADP, collagen, arachidonic acid, and PAF. It also inhibited the high potassium- and norepinephrine-induced contraction of rat thoracic aorta. In rat ventricular cells treated with 3 µM d-dicentrine, the action potential duration (ADP50) was prolonged from 59.9 ± 11.3 msec to 201 ± 28.7 msec.

Key words

Lindera megaphylla - d-dicentrine - anti-platelet aggregation - vasorelaxant - antiarrhythmic activity