Planta Medica, Inhaltsverzeichnis Planta Med 1991; 57(5): 414-416DOI: 10.1055/s-2006-960137 Papers © Georg Thieme Verlag Stuttgart · New York Hypoglycemic Effects of Sesquiterpene Glycosides and Polyhydroxylated Triterpenoids of Eriobotrya japonica Nunziatina De Tommasi1 , Francesco De Simone1 , Giuseppe Cirino2 , Carla Cicala2 , Cosimo Pizza1 1Dipartimento di Chimica delle Sostanze Naturali, Universita' di Napoli “Federico II”, Via D. Montesano 49, I-80131 Napoli, Italy 2Dipartimento di Farmacologia Sperimentale, Universita' di Napoli “Federico II”, Via D. Montesano 49, I-80131 Napoli, Italy Artikel empfehlen Abstract als PDF herunterladen Artikel einzeln kaufen Abstract The effects of the constituent sesquiterpene glycosides 1 - 3 and polyhydroxylated triterpenoids 5 - 6 isolated by MeOH extraction of Eriobotrya japonica were studied in genetically diabetic mice (C57BL/KS-db/db/Ola) and normoglycemic rats. The sesquiterpene glycoside 3 and the polyhydroxylated triterpenoids 5 and 6 produced a marked inhibition of glycosuria. Furthermore, 5 and 6 were able to reduce blood glucose levels in normoglycemic rats. While there are already some data reported on hypoglycemic activity of polyhydroxylated triterpenoids, there are no previous data showing hypoglycemic activity of sesquiterpene glycosides. Key words Eriobotrya japonica - hypoglycemic effects - sesquiterpene glycosides - polyhydroxylated triterpenoids PDF (275 kb)
