Cytotoxic Activity of Amaryllidaceae Alkaloids from Crinum augustum and Crinum bulbispermum

M. A. Abd El Hafiz; M. A. Ramadan; M. L. Jung; J. P. Beck; R. Anton

doi:10.1055/s-2006-960144

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Planta Med 1991; 57(5): 437-439
DOI: 10.1055/s-2006-960144

Papers

Cytotoxic Activity of Amaryllidaceae Alkaloids from Crinum augustum and Crinum bulbispermum

M. A. Abd El Hafiz¹ , M. A. Ramadan¹ , M. L. Jung² , J. P. Beck² , R. Anton³

¹Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt
²Laboratoire de Recherches en Immunologie, Université Louis Pasteur, F-67091 Strasbourg, France
³Laboratoire de Pharmacognosie, Faculté de Pharmacie, B.P. 24, F-67401 Illkirch Cédex, France

Further Information

Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

The cytotoxic activity of five minor Amaryllidaceae alkaloids and one flavan isolated from Crinum augustum Rox and Crinum bulbispermum Milne were tested on human leukemic Molt 4 cells. Whereas the crinine-type alkaloids (6α-hydroxycrinine, powelline) and the new type augustamine did not even inhibit the growth of Molt 4 cells, the lycorine-type alkaloid (pratorinine) and the crinine-type alkaloid (6α-hydroxybuphanisine) showed a moderate cytotoxic activity and the flavan (4′-hydroxy-7-methoxyflavan) showed an important cytotoxic effect.

Key words

Crinum augustum - Crinum bulbispermum - Amaryllidaceae alkaloids - cytotoxic effects - flavans