Download PDF
Planta Med 1991; 57(5): 444-446
DOI: 10.1055/s-2006-960146
Papers

© Georg Thieme Verlag Stuttgart · New York

Entzündungshemmende Sesquiterpenlactone von Achillea setacea*

Sesquiterpenelactones of Achillea setacea with Antiphlogistic Activity*K. Zitterl-Eglseer1 , J. Jurenitsch2 , S. Korhammer3 , E. Haslinger3 , S. Sosa4 , R. Della Loggia4 , W. Kubelka2 , Ch. Franz1
  • 1Institut für Botantik und Lebensmittelkunde der Veterinärmedizinischen Universität Wien, Linke Bahngasse 11, A-1030 Wien, Austria
  • 2Institut für Pharmakognosie der Universität Wien, Währinger Straße 25, A-1090 Wien, Austria
  • 3Laboratorium für Organische Chemie I der Universität Bayreuth, NW 2, Universitätsstraße 30, D-8580 Bayreuth, Federal Republic of Germany
  • 4Istituto di Farmacologia e Farmacognosia, Univ. Trieste, Via A. Valerio 32, I-34100 Trieste, Italy
* Teil eines gemeinsamen Forschungsprojektes von W. Kubelka, Ch. Franz, J. Jurenitsch und J. Saukel: „Auswahl von für die Züchtung geeigneten Schafgarben aus der Achillea millefolium-Gruppe”, unter Verwendung von Ergebnissen der Dissertation K. Eglseer, Universität Wien (1990)
Further Information

Publication History

1990

Publication Date:
05 January 2007 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

From the aerial parts of Achillea setacea W. & K. (Asteraceae) the main sesquiterpenes were isolated. Their structures were determined by means of 2D-NMR and MS as 11,13-dehydrodeacetylmatricarin (1) (=14-deoxylactucin), rupicolin A (2), and rupicolin B (3). These are the first compounds with an α-methylene-γ-lactone structure isolated from a species belonging to the Achillea millefolium aggregate. Achillicin, achillin, 8-hydroxyachillin, 8-acetoxyachillin, and matricin could not be detected in A. setacea. For both rupicolin B and 11,13-dehydrodeacetylmatricarin an anti-inflammatory activity was found in the croton oil ear test.

Key words

Achillea - sesquiterpene lactones - biological activity