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Planta Med 1991; 57(6): 519-522
DOI: 10.1055/s-2006-960197
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© Georg Thieme Verlag Stuttgart · New York

Activity of Boldine on Rat Ileum

H. Speisky1 , J. A. Squella2 , Luis J. Núñez-Vergara2
  • 1Biochemical Pharmacology Unit, Nutrition and Food Technology Institute (INTA), University of Chile, Santiago, Chile
  • 2Laboratory of Pharmacology & Electrochemistry, Faculty of Chemical & Pharmacological Sciences, University of Chile, PO Box 233, Santiago, Chile
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Publikationsverlauf

1990

Publikationsdatum:
05. Januar 2007 (online)

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Abstract

Boldine shows a concentration-dependent relaxation effect on the rat ileum preparation with a pD2 of 3.77 ± 0.12. The alkaloid also produces a concentration-dependent parallel shift of the curve-response to acetylcholine, therefore it directly interferes with the cholinergic mechanism associated with the contraction, behaving as a competitive antagonist with a pA2 of 4.78 ± 0.19. On the other hand, boldine produces a non-parallel shift of the contraction response induced by barium, revealing the occurrence of a non-competitive antagonism. This effect could be the result of interference with intracellular events associated with the barium-induced changes in calcium pools.

Key words

Boldine - Peumus boldus - (S)-2,9-dihydroxy-1,10-dimethoxyaporphine - muscle-relaxing effect - contractility of rat ileum