Anti-Hepatitic Activity of Ginesenoside Ro1

Hideaki Matsuda; Kei-ichi Samukawa; Michinori Kubo

doi:10.1055/s-2006-960198

Planta Medica, Table of Contents

Planta Med 1991; 57(6): 523-526
DOI: 10.1055/s-2006-960198

Papers

Anti-Hepatitic Activity of Ginesenoside Ro¹

Hideaki Matsuda, Kei-ichi Samukawa, Michinori Kubo

Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1, Kowakae, Higashiosaka, Osaka 577, Japan

1 Pharmacological Study on Panax ginseng C. A. Meyer; part XII. For part XI, see Matsuda, H., Samukawa, K., Kubo, M. (1990) Planta Med. 56, 19.

Abstract

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Abstract

Ginsenoside Ro, an oleanane-type saponin has been screened for activity in experimental models of acute and chronic hepatitis. Ginsenoside Ro (50 and 200 mg/kg, p.o.) inhibited the increase of serum glutamic oxaloacetic transaminase (s-GOT) and serum glutamic pyruvic transaminase (s-GPT) levels in D-galactosamine (GalN)- and carbon tetrachloride (CCl₄)-induced acute hepatitic rats. Ginsenoside Ro inhibited the increase of connective tissue in the liver of CCl₄-induced chronic hepatitic rats. Ginsenoside Ro showed a stronger inhibitory effect on the GalN-induced acute hepatitic model than those of the aglycone of ginsenoside Ro, oleanolic acid, or glycyrrhizic acid and its aglycone, glycyrrhetinic acid.

Key words

Panax ginseng - ginsenoside Ro - oleananetype saponin - D-galactosamine-induced hepatitis - carbon tetrachloride-induced hepatitis - connective tissue

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