A Novel Leishmanicidal Labdane from Polyalthia macropoda

Pascal Richomme; Marie-Chantal Godet; Françoise Foussard; Loïc Toupet; Thierry Sévenet; Jean Bruneton

doi:10.1055/s-2006-960204

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Planta Med 1991; 57(6): 552-554
DOI: 10.1055/s-2006-960204

Papers

A Novel Leishmanicidal Labdane from Polyalthia macropoda

Pascal Richomme¹ , Marie-Chantal Godet¹ , Françoise Foussard² , Loïc Toupet³ , Thierry Sévenet⁴ , Jean Bruneton¹

¹C.E.P.M., Faculté de Pharmacie, 16Bd Daviers, F-49100 Angers, France
²Laboratoire de Biochimie et de Biologie Cellulaire, Faculté de Pharmacie, 16 Bd Daviers, F-49100 Angers, France
³C.R.M.P.O, Campus de Beaulieu, F-35045 Rennes Cédex, France
⁴I.C.S.N., C.N.R.S., F-91190 Gif sur Yvette, France

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Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

A new diterpene, (4S,9R,10R) methyl 18-carboxy-labda-8,13(E)-diene-15-oate has been obtained from the stem barks of Polyalthia macropoda (Annonaceae). This labdanic derivative was identified on the basis of spectroscopic data and is biologically active against the promastigote Leishmania donovani donovani.

Key words

Polyalthia macropoda - Annonaceae - diterpene - labdane - leishmanicidal activity