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Planta Med 1991; 57: S21-S26
DOI: 10.1055/s-2006-960225
Physiology and Chemistry of Natural Products

© Georg Thieme Verlag Stuttgart · New York

Transport and Secretion of Natural Products in Plant Cell Cultures

Mamoru Tabata
  • Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Kyoto 606, Japan
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Publication Date:
05 January 2007 (online)

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Abstract

Using the example of berberine in cell cultures of Thalictrum and Berberis species, the transport and secretion of natural products in plant cell cultures is reviewed. Topics discussed are the subcellular localization of berberine biosynthesis, transport of berberine to vacuoles, extracellular release of berberine, mechanism of berberine secretion, uptake and transport of exogenous berberine, and the release of berberine by immobilized cells.

Key words

Plant cell cultures - Thalictrum - benzylisoquinoline alkaloids - alkaloid vesicles - active transport - berberine secretion - immobilized cells - bioreactor