Comparison Between in Vivo and in Vitro Metabolite Production of Morus nigra

Franco Ferrari; Barbara Monacelli; Irene Messana

doi:10.1055/s-2006-960448

Planta Medica, Inhaltsverzeichnis

Planta Med 1999; 65(1): 85-87
DOI: 10.1055/s-2006-960448

Letter

Comparison Between in Vivo and in Vitro Metabolite Production of Morus nigra

Franco Ferrari¹ , Barbara Monacelli² , Irene Messana¹

¹Istituto di Chimica e Chimica Clinica, Università Cattolica e Centra Chimica dei Recettori e delle Molecole Biologicamente Attive, C.N.R., Roma, Italy
²Dipartimento di Biologia Vegetale, Università “La Sapienza”, Roma, Italy

Abstract

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Abstract

Nine flavonoids and seven Diels-Alder type adducts were isolated from the acetonic extract of Morus nigra I. root bark, and three flavonoids and six Diels-Alder type adducts were isolated from the acetonic extract of M. nigra L. callus. However, none of the metabolites isolated from the root bark was found in the cell culture. Moreover, adducts isolated from the plant and cell culture showed not only a different cyclohexene ring substitution but also a different stereochemistry, that was found cis-trons in the metabolites isolated from callus, and trans-trans in those isolated from the root bark.

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