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Planta Med 1999; 65(1): 97-98
DOI: 10.1055/s-2006-960453
Letter

© Georg Thieme Verlag Stuttgart · New York

Inhibition of Chitin Synthase II by Catechins from Stem Bark of Taxus cuspidata

Sung-Uk Kim1 , Eui-Il Hwang1 , Ji-Youn Nam2 , Kwang-Hee Son1 , Song-Hae Bok2 , Hong-Eun Kim3 , Byoung-Mog Kwon2
  • 1Plant Protectants R.U., Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
  • 2Protein Regulator R.U., Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
  • 3Department of Forestry, College of Agriculture, Chungbuk National University, Cheongju, Korea
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Publication History

1998

1998

Publication Date:
04 January 2007 (online)

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Abstract

Two flavonoids, (±)-catechin and (-)-epicatechin, were isolated from the stem bark of Taxus cuspidata by monitoring chitin synthase II inhibitory activity. The compounds inhibit chitin synthase II with an IC50 of 15 and 29 µg/ml, respectively and appear to be selective for chitin synthase II. They did not inhibit chitin synthase III.