Structure-Activity Studies: In vitro Antileishmanial and Antimalarial Activities of Anthraquinones from Morinda lucida

A. A. Sittie; E. Lemmich; C. E. Olsen; L. Hviid; A. Kharazmi; F. K. Nkrumah; S. Brøgger Christensen

doi:10.1055/s-2006-960473

RSS-Feed abonnieren

Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.

https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000058.xml

Teilen / Bookmarken

Facebook X Linkedin Weibo

PDF herunterladen

Planta Med 1999; 65(3): 259-261
DOI: 10.1055/s-2006-960473

Letter

Structure-Activity Studies: In vitro Antileishmanial and Antimalarial Activities of Anthraquinones from Morinda lucida

A. A. Sittie¹ ^, ² , E. Lemmich¹ , C. E. Olsen³ , L. Hviid⁴ , A. Kharazmi⁴ , F. K. Nkrumah⁵ , S. Brøgger Christensen¹

¹Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen Ø, Denmark
²Centre for Scientific Research Into Plant Medicine, Mampong-Akwapim, Ghana
³Chemistry Department, Royal Veterinary and Agricultural University, Thorvaldsensvej, Frederiksberg C, Denmark
⁴Centre for Medical Parasitology, Copenhagen University Hospital (Rigshospitalet), Denmark
⁵Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana

Weitere Informationen

Publikationsverlauf

1998

1998

Publikationsdatum:
04. Januar 2007 (online)

Auch verfügbar auf

als PDF herunterladen Lizenzen und Reprints

Abstract

Anthraquinones have been isolated by bioassayguided fractionation from Morinda lucida. Structure-activity studies show that an aldehyde group at C-2 and a phenolic hydroxy group at C-3 enhance the activity of the anthraquinones against the growth of Plastnodium falciparum and promastigotes of Leishmania major in vitro.