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Planta Med 1999; 65(3): 261-262
DOI: 10.1055/s-2006-960474
Letter

© Georg Thieme Verlag Stuttgart · New York

Chitin Synthase II Inhibitory Activity of Ursolic Acid, Isolated from Crataegus pinnatifida

Tae-Sook Jeong1 , Eui-Il Hwang2 , Hyang-Bok Lee2 , Eun-Sook Lee1 , Young-Kook Kim1 , Byung-Sun Min3 , Ki-Hwan Bae3 , Song-Hae Bok1 , Sung-Uk Kim2
  • 1Protein Regulation R.U., Korea Research Institute of Bioscience and Biotechnology, Yusung, Taejon, Korea
  • 2Plant Protectans R.U., Korea Research Institute of Bioscience and Biotechnology, Yusung, Taejon, Korea
  • 3Department of Pharmacology, College of Pharmacy, Chungnam National University, Taejon, Korea
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Publication History

1998

1998

Publication Date:
04 January 2007 (online)

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Abstract

Two triterpenoid compounds, ursolic acid and uvaol, were isolated from Crataegus pinnatifida Bunge leaves. Ursolic acid inhibits chitin synthase II from S. cerevisiae with an IC50 value of 0.84 µg/ml and the inhibition appears to be selective for chitin synthase II, whereas uvaol has no inhibitory activity up to 280 µg/ml. Oleanolic acid, α-hederin hydrate, and betulic acid inhibited the chitin synthase II activity under the same conditions with an IC50 of 5.6, 64.3, and 98.7/ µg/ml, respectively.