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Planta Med 1999; 65(4): 374-375
DOI: 10.1055/s-2006-960792
Letters

© Georg Thieme Verlag Stuttgart · New York

Inhibitory Effect of Triterpenes from Crataegus pinatifida on HIV-I Protease

Byung Sun Min1 , 3 , Hyun Ju Jung1 , Jun Sung Lee1 , Young Ho Kim1 , Song Hae Bok2 , Chao Mei Ma3 , Norio Nakamura3 , Masao Hattori3 , KiHwan Bae1
  • 1College of Pharmacy, Chungnam National University, Taejon 305-764, Korea
  • 2Korea Research Institute of Bioscience & Biotechnology, Yusung, Taejon, Korea
  • 3Research Institute for Traditional Sino-Japanese Medicines, Toyama Medical and Pharmaceutical University, Toyama, Japan
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Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100 µg/ml. The subsequent fractionation and isolation of the extract gave two active compounds. Their structures were identified as uvaol (1) and ursolic acid (2) by spectral data. These active compounds inhibit HIV-1 protease with IC50 values of 5.5 and 8.0 µM, respectively.