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Planta Med 1999; 65(5): 437-439
DOI: 10.1055/s-2006-960803
DOI: 10.1055/s-2006-960803
Letter
© Georg Thieme Verlag Stuttgart · New York
α-Glucosidase Inhibitors from Commelina communis
Further Information
Publication History
1998
1999
Publication Date:
04 January 2007 (online)
Abstract
A methanolic extract of Commelina communis showed potent inhibitory activity against α-glucosidase. One pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), α-homonojirimycin (4) and 7-O-β-D-glucopyranosyl α-homonojirimycin (5) were isolated by bioassay-directed fractionation and separation. These compounds have been identified for the first time from Commelina communis, supporting the pharmacological basis of this plant that has been used as a traditional herbal medicine for the treatment of diabetes.