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Planta Med 1999; 65(5): 442-443
DOI: 10.1055/s-2006-960805
Letter

© Georg Thieme Verlag Stuttgart · New York

In vitro Anti-Helicobacter pylori Activity of Some Flavonoids and Their Metabolites

Eun-Ah Bae1 , Myung Joo Han1 , Dong-Hyun Kim2
  • 1Department of Food and Nutrition, Kyung-Hee University, Seoul, Korea
  • 2College of Pharmacy, Kyung-Hee University, Seoul, Korea
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Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

The inhibitory effect of flavonoids and phenolic acids, which could be transformed from flavonoids by human intestinal microflora, on the growth of Helicobocter pylori (HP) was investigated. Ponciretin, hesperetin, naringenin and diosmetin were active against HP. Among them, ponciretin was the most potent and its MIC was 10-20 µg/ml. However, these active compounds against HP did nearly not inhibit the urease activity of HP.