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Planta Med 1999; 65(5): 447-448
DOI: 10.1055/s-2006-960807
Letter

© Georg Thieme Verlag Stuttgart · New York

Azaanthraquinone: An Antimicrobial Alkaloid from Mitracarpus scaber

Adewole L. Okunade1 , Alice M. Clark2 , 3 , Charles D. Hufford2 , 3 , Babajide O. Oguntimein4
  • 1Department of Biology, Washington University in St. Louis, Missouri, U.S.A.
  • 2Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi, U.S.A.
  • 3Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi, U.S.A.
  • 4College of Pharmacy and Pharmaceutical Sciences, Howard University, Washington, U.S.A.
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Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

An ethanolic extract of the aerial parts of Mitracarpus scaber demonstrated good antimicrobial activity. Bioassay directed fractionation of this extract led to the isolation of benz[g]isoquinoline-5,10-dione (1) as an active component. Compound 1 showed significant in vitro inhibitory activity against the AIDS-related pathogens.