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Planta Med 1999; 65(5): 450-452
DOI: 10.1055/s-2006-960809
Letter

© Georg Thieme Verlag Stuttgart · New York

Antimicrobial Activity and Stability of Tingenone Derivatives

Uthai Sotanaphun1 , Vimolmas Lipipun2 , Rutt Suttisri2 , Rapepol Bavovada2
  • 1Faculty of Pharmacy, Silpakorn University, Nakorn-Pathom, Thailand
  • 2Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
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Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

Quinone-methide triterpenes of the tingenone series were evaluated for their antimicrobial activity. These compounds were effective against Bacillus cereus, B. subtilis, Sarcinalutea, Staphylococcus aureus, Microsporum gypseum and a Gramnegative bacterium, Klebsiella pneumoniae. Under acidic conditions, the quinone-methide part of these compounds rear ranged into the divinyl-phenolic system, and the antimicrobial activity was thus lost.