Planta Med 1999; 65(7): 664-666
DOI: 10.1055/s-2006-960843
Letter

© Georg Thieme Verlag Stuttgart · New York

Anti-Tumor-Promoting Rearranged Abietane Diterpenes from the Leaves of Larix kaempferi

Hironori Ohtsu1 , Reiko Tanaka1 , Shunyo Matsunaga1 , Harukuni Tokuda2 , Hoyoku Nishino2
  • 1Department of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
  • 2Department of Biochemistry, Kyoto Prefectural University of Medicine, Kyoto, Japan
Further Information

Publication History

1999

1999

Publication Date:
04 January 2007 (online)

Abstract

Two novel rearranged abietane-type diterpene acids, karamatsuic acid (1) and larikaempferic acid (2) were isolated as their corresponding methyl esters, 1a and 2a, from the leaves of Larix kaempferi (Lamb.) Carr. Their structures were established as 9,10α-epoxy-9,10-seco-abieta-8,11,13-trien-18-oic acid and 9α,13α-epoxy-8-oxo-9(8→7)abeo-7βH-abietan-18-oic acid, respectively, by spectral evidence. Compounds 1a, 2a and 12,15-dihydroxydehydroabietic acid (3) exhibited potent inhibitory effects against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells.