Antiplasmodial Activity of Knipholone and Related Natural Phenylanthraquinones

Gerhard Bringmann; Dirk Menche; Merhatibeb Bezabih; Berhanu M. Abegaz; Ronald Kaminsky

doi:10.1055/s-2006-960859

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Planta Med 1999; 65(8): 757-758
DOI: 10.1055/s-2006-960859

Letters

Antiplasmodial Activity of Knipholone and Related Natural Phenylanthraquinones

Gerhard Bringmann¹ , Dirk Menche¹ , Merhatibeb Bezabih² , Berhanu M. Abegaz² , Ronald Kaminsky³

¹Institut für Organische Chemie der Universität, Würzburg, Germany
²Department of Chemistry, University of Botswana, Gaborone, Botswana
³Schweizerisches Tropeninstitut, Basel, Switzerland

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Publication History

1999

1999

Publication Date:
04 January 2007 (online)

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Abstract

The phenylanthraquinone knipholone (1) and three of its natural derivatives as well as seven structurally related but simplified compounds have been examined for their antiplasmodial activity against asexual erythrocytic stages of two strains of Plasmodium falciparum in vitro (K1/chloroquine-resistant and NF 54/chloroquine-sensitive). All the phenylanthraquinones showed considerable activity with only little cytotoxicity, while their anthraquinone and phenyl moieties were completely inactive. Knipholone (1) and its natural derivatives can therefore be considered as a new group of potential antimalarials.