Bioactive Indole Alkaloids from the Bark of Uncaria guianensis

Kit K. Lee; Bing-Nan Zhou; David G. I. Kingston; Abraham J. Vaisberg; Gerald B. Hammond

doi:10.1055/s-2006-960860

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Planta Med 1999; 65(8): 759-760
DOI: 10.1055/s-2006-960860

Letters

Bioactive Indole Alkaloids from the Bark of Uncaria guianensis

Kit K. Lee¹ , Bing-Nan Zhou¹ , David G. I. Kingston¹ , Abraham J. Vaisberg² , Gerald B. Hammond³

¹Department of Chemistry, Virginia Polytechnic and State University, Blacksburg, Virginia, USA
²Departamento de Microbiologia, Universidad Peruana Cayetano Heredia, Lima, Peru
³Department of Chemistry and Biochemistry, University of Massachusetts, Dartmouth, Massachusetts, USA

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1999

1999

Publication Date:
04 January 2007 (online)

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Abstract

Bioassay-guided fractionation of the EtOH extract of the bark of Uncaria guianensis (Aubl.) Cmel (Rubiaceae) using a yeast-based assay for DNA-damaging agents has furnished the two weakly but selectively active indole alkaloids uncarine C (1) and uncarine E (2) as the major bioactive constituents in this assay.