Fukiic and Piscidic Acid Esters from the Rhizome of Cimicifuga racemosa and the in vitro Estrogenic Activity of Fukinolic Acid

Sven O. Kruse; Anke Löhning; Guido F. Pauli; Hilke Winterhoff; Adolf Nahrstedt

doi:10.1055/s-2006-960862

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Planta Med 1999; 65(8): 763-764
DOI: 10.1055/s-2006-960862

Letters

Fukiic and Piscidic Acid Esters from the Rhizome of Cimicifuga racemosa and the in vitro Estrogenic Activity of Fukinolic Acid

Sven O. Kruse¹ , Anke Löhning² , Guido F. Pauli¹ , Hilke Winterhoff² , Adolf Nahrstedt²

¹Institut für Pharmazeutische Biologie und Phytochemie, Münster, Germany
²Institut für Pharmakologie und Toxikologie, Münster, Germany

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Publication History

1999

1999

Publication Date:
04 January 2007 (online)

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Abstract

Hydroxycinnamic acid esters of fukiic acid and piscidic acid were isolated from a 50% ethanolic extract obtained from the rhizomes of Cimicifuga racemosa (Ranunculaceae). Besides 2-E-caffeoylfukiic acid (fukinolic acid), 2-E-feruloylfukiic acid (cimicifugic acid A), 2-E-isoferuloylfukiic acid (cimicifugic acid B), 2-E-feruloylpiscidic acid (cimicifugic acid E) and 2-E-isoferuloylpiscidic acid (cimicifugic acid F), free caffeic, ferulic and isoferulic acids were isolated. The estrogenic activity of fukinolic acid was shown by increased proliferation (126% at 5 × 10^-8 M) of an estrogen dependent MCF-7 cell system with reference to estradiol (120% at 10^-10 M).