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Planta Med 1990; 56(1): 19-23
DOI: 10.1055/s-2006-960875
Paper

© Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory Activity of Ginsenoside Ro1

Hideaki Matsuda2 , Kei-ichi Samukawa3 , Michinori Kubo2
  • 2Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1, Kowakae, Higashiosaka, Osaka 577, Japan
  • 3Ginseng Institute, Japan Korea Red Ginseng Co. Ltd., 4-1-12, Sakaemachidori, Chuoku, Kobe, 650, Japan
1 Pharmacological Study on Panax ginseng C. A. Meyer; part XI. For part X, see Kubo, M., Samukawa, K., Matsuda, H. (1989) J. Med. Pharm. Soc. Wakan-Yaku 6, 45.
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Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

Ginsenoside Ro, an oleanane-type saponin has been screened for activity in experimental models of inflammation. Ginsenoside Ro (10,50, and 200 mg/kg, p. o.) inhibited an increase in vascular permeability in mice induced by acetic acid and reduced an acute paw edema in rats induced by compound 48/80 or carrageenin. Ginsenoside Ro did not suppress a developing adjuvant-induced edema in arthritic rats. However, ginsenoside Ro was found to be effective in hypercoagulable state, increase of connective tissue in the artery and calcium effluence from the bone in adjuvant-induced arthritic rats

Key words

Panax ginseng - ginsenoside Ro - inflammation - adjuvant-induced arthritis - connective tissue - clacium effluence