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Planta Med 1990; 56(1): 24-26
DOI: 10.1055/s-2006-960876
Paper

© Georg Thieme Verlag Stuttgart · New York

Pharmacological Effects of Three Phenylpropanoid Glycosides from Mussatia

Ernesto Cano1 , Manuel Veiga2 , Carlos Jiménez3 , Ricardo Riguera3
  • 1Departamento de Farmacología, Farmaciay Tecnología Farmacéutica, Facultad de Farmacia, Santiago de Compostela, Spain
  • 2Departamento de Microbiología y Parasitología, Facultad de Farmacia, Santiago de Compostela, Spain
  • 3Departamento de Química Orgánica, Santiago de Compostela, Spain
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1988

Publikationsdatum:
05. Januar 2007 (online)

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Abstract

The phenylpropanoid glycosides 1 (4-cinnamoylmussatioside), 2 (4-dimethylcaffeoylmussatioside), and 3 (4-p-methoxycinnamoylmussatioside) isolated from the methanolic extract of Mussatia sp. showed inhibitory action on ADP-induced rat platelet aggregation. The order of activity was 1 > 2 > 3. This antiplatelet effect is likely to be related to the reported inhibition of cAMP-phosphodiesterase. On the other hand, compounds 1-3 had no effect on blood pressure and heart rate, on microbial growth, or on prostaglandin biosynthesis.

Key words

Mussatia - phenylpropanoid glycosides - mussatiosides - pharmacological activity