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Planta Med 1990; 56(1): 36-40
DOI: 10.1055/s-2006-960879
Paper

© Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory Activity and Sub-Acute Toxicity of Artemetin1

Jayme A. A. Sertié2 , Aulus C. Basile2 , Sylvio Panizza3 , Amabile K. Matida4 , Raymond Zelnik4
  • 1Pharmacological Investigations on Cordia verbenacea; Part 2. For part 1, see Ref. (1).
  • 2Department of Pharmacology, Instituto de Ciências Biomedicas, Universidade de São Paulo, Caixa Postal 4365, Sao Paulo, Brasil
  • 3Department of Botany, Instituto de Biociências, Universidade de São Paulo, Caixa Postal 11461, São Paulo, Brasil
  • 4Serviço de Química Orgânica, Instituto Butantan, Caixa Postal 65, São Paulo, Brasil
Further Information

Publication History

1988

Publication Date:
05 January 2007 (online)

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Abstract

The 5-hydroxy-3,6,7,3′,4′-pentameth-oxyflavone (artemetin) from Cordia verbenacea DC (Boraginaceae) showed marked anti-inflammatory activity using various experimental models in rats. Artemetin significantly inhibited carrageenin-induced paw edema following oral doses from 30.4 to 153.9 mg.kg-1. The doses of 102.6 and 153.9 mg.kg-1 showed an inhibitory effect similar to that of 50.0 mg.kg-1 of calcium phenylbutazone. The ED50 value of artemetin in rats was estimated to be 67.07 mg.kg-1. Repeated administration of artemetin at doses of 67.07 mg.kg-1 for a 6-day period reduced granuloma formation with a response comparable to that of 20.0 mg.kg-1 of calcium phenylbutazone. This same dose of artemetin also reduced the vascular permeability to intracutaneous histamine. Sub-acute toxicological experiments indicated a very low toxicity.

Key words

Cordia verbenacea - Boraginaceae - Artemetin - anti-inflammatory activity - sub-acute toxicity