Planta Medica, Table of Contents Planta Med 1990; 56(1): 36-40DOI: 10.1055/s-2006-960879 Paper © Georg Thieme Verlag Stuttgart · New YorkAnti-Inflammatory Activity and Sub-Acute Toxicity of Artemetin1 Jayme A. A. Sertié2 , Aulus C. Basile2 , Sylvio Panizza3 , Amabile K. Matida4 , Raymond Zelnik4 1Pharmacological Investigations on Cordia verbenacea; Part 2. For part 1, see Ref. (1). 2Department of Pharmacology, Instituto de Ciências Biomedicas, Universidade de São Paulo, Caixa Postal 4365, Sao Paulo, Brasil 3Department of Botany, Instituto de Biociências, Universidade de São Paulo, Caixa Postal 11461, São Paulo, Brasil 4Serviço de Química Orgânica, Instituto Butantan, Caixa Postal 65, São Paulo, Brasil Recommend Article Abstract PDF Download(opens in new window) Buy Article(opens in new window) Abstract The 5-hydroxy-3,6,7,3′,4′-pentameth-oxyflavone (artemetin) from Cordia verbenacea DC (Boraginaceae) showed marked anti-inflammatory activity using various experimental models in rats. Artemetin significantly inhibited carrageenin-induced paw edema following oral doses from 30.4 to 153.9 mg.kg-1. The doses of 102.6 and 153.9 mg.kg-1 showed an inhibitory effect similar to that of 50.0 mg.kg-1 of calcium phenylbutazone. The ED50 value of artemetin in rats was estimated to be 67.07 mg.kg-1. Repeated administration of artemetin at doses of 67.07 mg.kg-1 for a 6-day period reduced granuloma formation with a response comparable to that of 20.0 mg.kg-1 of calcium phenylbutazone. This same dose of artemetin also reduced the vascular permeability to intracutaneous histamine. Sub-acute toxicological experiments indicated a very low toxicity. Key words Cordia verbenacea - Boraginaceae - Artemetin - anti-inflammatory activity - sub-acute toxicity PDF (440 kb)
