In Vitro Activity of Protoanemonin, an Antifungal Agent

M. Luisa Martín; Luis San Román; Angel Domínguez

doi:10.1055/s-2006-960886

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Planta Med 1990; 56(1): 66-69
DOI: 10.1055/s-2006-960886

Paper

In Vitro Activity of Protoanemonin, an Antifungal Agent

M. Luisa Martín¹ , Luis San Román¹ , Angel Domínguez²

¹Departamento de Fisiologia y Farmacología, Universidad de Salamanca, 37071 Salamanca, Spain
²Departamento de Microbiología, Genética, Medicina Preventiva y Salud Pública, Universidad de Salamanca, 37071 Salamanca, Spain

Further Information

Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

Protoanemonin, the lactone of γ-hydroxyvinylacrylic acid, isolated from Pulsatilla alpina has in vitro activity against fungi. The MIC is 15 µg/ml and RNA inhibition seems to be the first target of the drug. The LD₅₀ of protoanemonin in male Swiss albino mice was 190 mg/kg.

Key words

Pulsatilla alpina - Ranunculaceae - protoanemonin - anti Fungal