Planta Medica, Table of Contents Planta Med 1990; 56(1): 66-69DOI: 10.1055/s-2006-960886 Paper © Georg Thieme Verlag Stuttgart · New York In Vitro Activity of Protoanemonin, an Antifungal Agent M. Luisa Martín1 , Luis San Román1 , Angel Domínguez2 1Departamento de Fisiologia y Farmacología, Universidad de Salamanca, 37071 Salamanca, Spain 2Departamento de Microbiología, Genética, Medicina Preventiva y Salud Pública, Universidad de Salamanca, 37071 Salamanca, Spain Recommend Article Abstract PDF Download Buy Article Abstract Protoanemonin, the lactone of γ-hydroxyvinylacrylic acid, isolated from Pulsatilla alpina has in vitro activity against fungi. The MIC is 15 µg/ml and RNA inhibition seems to be the first target of the drug. The LD50 of protoanemonin in male Swiss albino mice was 190 mg/kg. Key words Pulsatilla alpina - Ranunculaceae - protoanemonin - anti Fungal PDF (801 kb)
